Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1461890..1462571 Replicon chromosome
Accession NZ_CP124600
Organism Pseudomonas aeruginosa strain Li010

Toxin (Protein)


Gene name higB Uniprot ID V6AKP0
Locus tag QIU11_RS06880 Protein ID WP_003111825.1
Coordinates 1461890..1462255 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QIU11_RS06885 Protein ID WP_003145733.1
Coordinates 1462248..1462571 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QIU11_RS06850 (QIU11_06850) 1457886..1458320 - 435 WP_003116494.1 RidA family protein -
QIU11_RS06855 (QIU11_06855) 1458541..1459494 + 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
QIU11_RS06860 (QIU11_06860) 1459467..1460351 - 885 WP_003158600.1 LysR family transcriptional regulator -
QIU11_RS06865 (QIU11_06865) 1460452..1460877 + 426 WP_003114206.1 VOC family protein -
QIU11_RS06870 (QIU11_06870) 1460908..1461180 - 273 WP_023090041.1 hypothetical protein -
QIU11_RS06875 (QIU11_06875) 1461387..1461626 + 240 WP_044060930.1 hypothetical protein -
QIU11_RS06880 (QIU11_06880) 1461890..1462255 + 366 WP_003111825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QIU11_RS06885 (QIU11_06885) 1462248..1462571 + 324 WP_003145733.1 XRE family transcriptional regulator Antitoxin
QIU11_RS06890 (QIU11_06890) 1462935..1464023 - 1089 WP_031652783.1 DUF3396 domain-containing protein -
QIU11_RS06895 (QIU11_06895) 1464040..1464486 - 447 WP_031764396.1 VRR-NUC domain-containing protein -
QIU11_RS06900 (QIU11_06900) 1464553..1464741 - 189 WP_023090039.1 hypothetical protein -
QIU11_RS06905 (QIU11_06905) 1464738..1465256 - 519 WP_031764395.1 PAAR domain-containing protein -
QIU11_RS06910 (QIU11_06910) 1465430..1465765 - 336 WP_003140884.1 TM2 domain-containing protein -
QIU11_RS06915 (QIU11_06915) 1466008..1466646 - 639 WP_003140882.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1459467..1508345 48878


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13880.24 Da        Isoelectric Point: 4.8219

>T280862 WP_003111825.1 NZ_CP124600:1461890-1462255 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYELNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11896.73 Da        Isoelectric Point: 6.4751

>AT280862 WP_003145733.1 NZ_CP124600:1462248-1462571 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AKP0

Antitoxin

Source ID Structure

References