Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3811439..3812102 Replicon chromosome
Accession NZ_CP124548
Organism Actinomyces israelii strain F0345

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag AIF0345_RS15835 Protein ID WP_285296679.1
Coordinates 3811439..3811804 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AIF0345_RS15840 Protein ID WP_285296680.1
Coordinates 3811788..3812102 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AIF0345_RS15820 3807520..3808554 + 1035 WP_285296676.1 alpha/beta hydrolase-fold protein -
AIF0345_RS15825 3809542..3811122 + 1581 WP_285296677.1 ATP-binding protein -
AIF0345_RS15830 3811086..3811262 + 177 WP_285296678.1 helix-turn-helix domain-containing protein -
AIF0345_RS15835 3811439..3811804 + 366 WP_285296679.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AIF0345_RS15840 3811788..3812102 + 315 WP_285296680.1 XRE family transcriptional regulator Antitoxin
AIF0345_RS15845 3812313..3813800 - 1488 WP_084682631.1 sugar porter family MFS transporter -
AIF0345_RS15850 3814056..3814943 - 888 WP_285296681.1 hypothetical protein -
AIF0345_RS15855 3815282..3816448 - 1167 WP_285296682.1 ISAs1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3811439..3824531 13092


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-108)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14055.84 Da        Isoelectric Point: 4.6456

>T280856 WP_285296679.1 NZ_CP124548:3811439-3811804 [Actinomyces israelii]
VAWEVILWEDVESWLLSLDDVSYDLVAAAIDHLAAVGPTLGRPLVDLLIGSHYHNLKELRPGSSERSEIRILFAFDSRRR
AVLLIAGDKRGRWQQWYRESIPLAELRFDQWLRESNNDENE

Download         Length: 366 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11464.87 Da        Isoelectric Point: 8.6994

>AT280856 WP_285296680.1 NZ_CP124548:3811788-3812102 [Actinomyces israelii]
MTRTSSWEAVRRRRPPHESAVTEHRARFAAEQTAYRLREIREQQGLTQAEVAERMGLTQPTVSALESGDLSRSGLATLHA
YITALGGTVEVTAAFGDQRLIIAT

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References