Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4494629..4495231 Replicon chromosome
Accession NZ_CP124522
Organism Salmonella enterica strain PNUSAS118467

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag QJS74_RS21820 Protein ID WP_001159635.1
Coordinates 4494920..4495231 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJS74_RS21815 Protein ID WP_000362050.1
Coordinates 4494629..4494919 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJS74_RS21800 (4492122) 4492122..4493024 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
QJS74_RS21805 (4493021) 4493021..4493656 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
QJS74_RS21810 (4493653) 4493653..4494582 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
QJS74_RS21815 (4494629) 4494629..4494919 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
QJS74_RS21820 (4494920) 4494920..4495231 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
QJS74_RS21825 (4495449) 4495449..4496378 + 930 WP_001127705.1 alpha/beta hydrolase -
QJS74_RS21830 (4496464) 4496464..4496775 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
QJS74_RS21835 (4496772) 4496772..4497218 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
QJS74_RS21840 (4497233) 4497233..4498174 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
QJS74_RS21845 (4498219) 4498219..4498656 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
QJS74_RS21850 (4498653) 4498653..4499525 - 873 WP_000921423.1 virulence factor BrkB family protein -
QJS74_RS21855 (4499519) 4499519..4500118 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T280828 WP_001159635.1 NZ_CP124522:c4495231-4494920 [Salmonella enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT280828 WP_000362050.1 NZ_CP124522:c4494919-4494629 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References