Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3408882..3409484 Replicon chromosome
Accession NZ_CP124517
Organism Escherichia coli strain AVS0343

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QJB09_RS16825 Protein ID WP_000897302.1
Coordinates 3408882..3409193 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJB09_RS16830 Protein ID WP_000356397.1
Coordinates 3409194..3409484 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB09_RS16800 (3404796) 3404796..3405395 + 600 WP_001296610.1 glucose-1-phosphatase -
QJB09_RS16805 (3405389) 3405389..3406261 + 873 WP_000920762.1 virulence factor BrkB family protein -
QJB09_RS16810 (3406258) 3406258..3406695 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QJB09_RS16815 (3406740) 3406740..3407681 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QJB09_RS16820 (3407745) 3407745..3408653 - 909 WP_001385591.1 alpha/beta hydrolase -
QJB09_RS16825 (3408882) 3408882..3409193 + 312 WP_000897302.1 hypothetical protein Toxin
QJB09_RS16830 (3409194) 3409194..3409484 + 291 WP_000356397.1 NadS family protein Antitoxin
QJB09_RS16835 (3409843) 3409843..3410121 + 279 WP_001296612.1 hypothetical protein -
QJB09_RS16840 (3410518) 3410518..3410736 + 219 WP_001251293.1 CopG family transcriptional regulator -
QJB09_RS16845 (3410921) 3410921..3411661 - 741 WP_000608806.1 hypothetical protein -
QJB09_RS16850 (3411686) 3411686..3412534 - 849 WP_001038650.1 hypothetical protein -
QJB09_RS16855 (3412824) 3412824..3413066 + 243 WP_001068514.1 CopG family transcriptional regulator -
QJB09_RS16860 (3413248) 3413248..3414177 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T280795 WP_000897302.1 NZ_CP124517:3408882-3409193 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT280795 WP_000356397.1 NZ_CP124517:3409194-3409484 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References