Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2595405..2596204 Replicon chromosome
Accession NZ_CP124517
Organism Escherichia coli strain AVS0343

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJB09_RS12845 Protein ID WP_000347251.1
Coordinates 2595740..2596204 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJB09_RS12840 Protein ID WP_001296435.1
Coordinates 2595405..2595740 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB09_RS12825 (2591190) 2591190..2591960 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QJB09_RS12830 (2591976) 2591976..2593310 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJB09_RS12835 (2593685) 2593685..2595256 + 1572 WP_001273763.1 galactarate dehydratase -
QJB09_RS12840 (2595405) 2595405..2595740 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJB09_RS12845 (2595740) 2595740..2596204 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJB09_RS12850 (2596259) 2596259..2597068 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJB09_RS12855 (2597317) 2597317..2598597 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJB09_RS12860 (2598620) 2598620..2599093 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJB09_RS12865 (2599104) 2599104..2599883 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJB09_RS12870 (2599873) 2599873..2600751 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJB09_RS12875 (2600769) 2600769..2601203 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T280793 WP_000347251.1 NZ_CP124517:2595740-2596204 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT280793 WP_001296435.1 NZ_CP124517:2595405-2595740 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References