Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2000703..2001205 Replicon chromosome
Accession NZ_CP124513
Organism Escherichia coli strain AVS0366

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QJP86_RS09505 Protein ID WP_000767822.1
Coordinates 2000951..2001205 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJP86_RS09500 Protein ID WP_001259255.1
Coordinates 2000703..2000954 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP86_RS09475 (1995881) 1995881..1996948 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QJP86_RS09480 (1996948) 1996948..1998018 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
QJP86_RS09485 (1998015) 1998015..1999319 - 1305 WP_001546022.1 histidinol dehydrogenase -
QJP86_RS09490 (1999325) 1999325..2000224 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP86_RS09495 (2000370) 2000370..2000420 - 51 WP_001364200.1 his operon leader peptide -
QJP86_RS09500 (2000703) 2000703..2000954 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP86_RS09505 (2000951) 2000951..2001205 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP86_RS09510 (2001288) 2001288..2002112 + 825 WP_000754737.1 SDR family oxidoreductase -
QJP86_RS09515 (2002158) 2002158..2003087 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP86_RS09520 (2003302) 2003302..2003364 + 63 WP_010723108.1 membrane protein YoeI -
QJP86_RS09525 (2003354) 2003354..2004712 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T280741 WP_000767822.1 NZ_CP124513:2000951-2001205 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT280741 WP_001259255.1 NZ_CP124513:2000703-2000954 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References