Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4965465..4965967 Replicon chromosome
Accession NZ_CP124511
Organism Escherichia coli strain AVS0501

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QJP59_RS24105 Protein ID WP_000767822.1
Coordinates 4965713..4965967 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJP59_RS24100 Protein ID WP_001259255.1
Coordinates 4965465..4965716 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP59_RS24075 (4960643) 4960643..4961710 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QJP59_RS24080 (4961710) 4961710..4962780 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
QJP59_RS24085 (4962777) 4962777..4964081 - 1305 WP_001546022.1 histidinol dehydrogenase -
QJP59_RS24090 (4964087) 4964087..4964986 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP59_RS24095 (4965132) 4965132..4965182 - 51 WP_001364200.1 his operon leader peptide -
QJP59_RS24100 (4965465) 4965465..4965716 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP59_RS24105 (4965713) 4965713..4965967 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP59_RS24110 (4966050) 4966050..4966874 + 825 WP_000754737.1 SDR family oxidoreductase -
QJP59_RS24115 (4966920) 4966920..4967849 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP59_RS24120 (4968064) 4968064..4968126 + 63 WP_010723108.1 membrane protein YoeI -
QJP59_RS24125 (4968116) 4968116..4969474 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T280733 WP_000767822.1 NZ_CP124511:4965713-4965967 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT280733 WP_001259255.1 NZ_CP124511:4965465-4965716 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References