Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3571761..3572560 Replicon chromosome
Accession NZ_CP124511
Organism Escherichia coli strain AVS0501

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP59_RS17605 Protein ID WP_000347251.1
Coordinates 3571761..3572225 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP59_RS17610 Protein ID WP_001296435.1
Coordinates 3572225..3572560 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP59_RS17575 (3566762) 3566762..3567196 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QJP59_RS17580 (3567214) 3567214..3568092 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP59_RS17585 (3568082) 3568082..3568861 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP59_RS17590 (3568872) 3568872..3569345 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP59_RS17595 (3569368) 3569368..3570648 - 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP59_RS17600 (3570897) 3570897..3571706 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP59_RS17605 (3571761) 3571761..3572225 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP59_RS17610 (3572225) 3572225..3572560 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP59_RS17615 (3572709) 3572709..3574280 - 1572 WP_001273763.1 galactarate dehydratase -
QJP59_RS17620 (3574655) 3574655..3575989 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP59_RS17625 (3576005) 3576005..3576775 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T280729 WP_000347251.1 NZ_CP124511:c3572225-3571761 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT280729 WP_001296435.1 NZ_CP124511:c3572560-3572225 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References