280727

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 3151692..3153010 Replicon chromosome
Accession NZ_CP124511
Organism Escherichia coli strain AVS0501

Toxin (Protein)


Gene name HipT Uniprot ID F4T5A3
Locus tag QJP59_RS15495 Protein ID WP_001262467.1
Coordinates 3152003..3153010 (+) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F4T5A4
Locus tag QJP59_RS15490 Protein ID WP_001312177.1
Coordinates 3151692..3152003 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP59_RS15465 (3147224) 3147224..3148243 + 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -
QJP59_RS15470 (3148253) 3148253..3149155 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
QJP59_RS15475 (3149166) 3149166..3150149 + 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
QJP59_RS15480 (3150146) 3150146..3151159 + 1014 WP_000103572.1 dipeptide ABC transporter ATP-binding subunit DppF -
QJP59_RS15485 (3151384) 3151384..3151707 + 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
QJP59_RS15490 (3151692) 3151692..3152003 + 312 WP_001312177.1 HipA N-terminal domain-containing protein Antitoxin
QJP59_RS15495 (3152003) 3152003..3153010 + 1008 WP_001262467.1 HipA domain-containing protein Toxin
QJP59_RS15500 (3153027) 3153027..3154298 - 1272 WP_001545666.1 amino acid permease -
- (3154660) 3154660..3154725 - 66 NuclAT_27 - -
- (3154660) 3154660..3154725 - 66 NuclAT_27 - -
- (3154660) 3154660..3154725 - 66 NuclAT_27 - -
- (3154660) 3154660..3154725 - 66 NuclAT_27 - -
QJP59_RS15505 (3154774) 3154774..3154881 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- (3155143) 3155143..3155200 - 58 NuclAT_26 - -
- (3155143) 3155143..3155200 - 58 NuclAT_26 - -
- (3155143) 3155143..3155200 - 58 NuclAT_26 - -
- (3155143) 3155143..3155200 - 58 NuclAT_26 - -
QJP59_RS15510 (3155257) 3155257..3155364 + 108 WP_000170748.1 type I toxin-antitoxin system toxin Ldr family protein -
QJP59_RS15515 (3155740) 3155740..3155847 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
QJP59_RS15520 (3155933) 3155933..3157612 - 1680 Protein_3034 cellulose biosynthesis protein BcsG -
QJP59_RS15525 (3157609) 3157609..3157800 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38320.60 Da        Isoelectric Point: 5.5965

>T280727 WP_001262467.1 NZ_CP124511:3152003-3153010 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11821.47 Da        Isoelectric Point: 6.0609

>AT280727 WP_001312177.1 NZ_CP124511:3151692-3152003 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K2ZTB5

Antitoxin

Source ID Structure
AlphaFold DB A0A3L3HKE2

References