Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1923700..1924202 Replicon chromosome
Accession NZ_CP124508
Organism Escherichia coli strain AVS0068

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QJB02_RS09120 Protein ID WP_000767822.1
Coordinates 1923948..1924202 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJB02_RS09115 Protein ID WP_001259255.1
Coordinates 1923700..1923951 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB02_RS09090 (1918878) 1918878..1919945 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QJB02_RS09095 (1919945) 1919945..1921015 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
QJB02_RS09100 (1921012) 1921012..1922316 - 1305 WP_001546022.1 histidinol dehydrogenase -
QJB02_RS09105 (1922322) 1922322..1923221 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJB02_RS09110 (1923367) 1923367..1923417 - 51 WP_001364200.1 his operon leader peptide -
QJB02_RS09115 (1923700) 1923700..1923951 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJB02_RS09120 (1923948) 1923948..1924202 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJB02_RS09125 (1924285) 1924285..1925109 + 825 WP_000754737.1 SDR family oxidoreductase -
QJB02_RS09130 (1925155) 1925155..1926084 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJB02_RS09135 (1926299) 1926299..1926361 + 63 WP_010723108.1 membrane protein YoeI -
QJB02_RS09140 (1926351) 1926351..1927709 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T280697 WP_000767822.1 NZ_CP124508:1923948-1924202 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT280697 WP_001259255.1 NZ_CP124508:1923700-1923951 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References