280668

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 4891288..4892606 Replicon chromosome
Accession NZ_CP124502
Organism Escherichia coli strain AVS0970

Toxin (Protein)


Gene name HipT Uniprot ID F4T5A3
Locus tag QJP73_RS23695 Protein ID WP_001262467.1
Coordinates 4891288..4892295 (-) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F4T5A4
Locus tag QJP73_RS23700 Protein ID WP_001312177.1
Coordinates 4892295..4892606 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP73_RS23675 (4887464) 4887464..4887655 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
QJP73_RS23680 (4887652) 4887652..4889331 + 1680 Protein_4630 cellulose biosynthesis protein BcsG -
QJP73_RS23685 (4889417) 4889417..4889524 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- (4889573) 4889573..4889638 + 66 NuclAT_26 - -
- (4889573) 4889573..4889638 + 66 NuclAT_26 - -
- (4889573) 4889573..4889638 + 66 NuclAT_26 - -
- (4889573) 4889573..4889638 + 66 NuclAT_26 - -
QJP73_RS23690 (4890000) 4890000..4891271 + 1272 WP_001545666.1 amino acid permease -
QJP73_RS23695 (4891288) 4891288..4892295 - 1008 WP_001262467.1 HipA domain-containing protein Toxin
QJP73_RS23700 (4892295) 4892295..4892606 - 312 WP_001312177.1 HipA N-terminal domain-containing protein Antitoxin
QJP73_RS23705 (4892591) 4892591..4892914 - 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
QJP73_RS23710 (4893139) 4893139..4894152 - 1014 WP_000103572.1 dipeptide ABC transporter ATP-binding subunit DppF -
QJP73_RS23715 (4894149) 4894149..4895132 - 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
QJP73_RS23720 (4895143) 4895143..4896045 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
QJP73_RS23725 (4896055) 4896055..4897074 - 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38320.60 Da        Isoelectric Point: 5.5965

>T280668 WP_001262467.1 NZ_CP124502:c4892295-4891288 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11821.47 Da        Isoelectric Point: 6.0609

>AT280668 WP_001312177.1 NZ_CP124502:c4892606-4892295 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K2ZTB5

Antitoxin

Source ID Structure
AlphaFold DB A0A3L3HKE2

References