Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4472794..4473593 Replicon chromosome
Accession NZ_CP124502
Organism Escherichia coli strain AVS0970

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP73_RS21600 Protein ID WP_000347251.1
Coordinates 4473129..4473593 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP73_RS21595 Protein ID WP_001296435.1
Coordinates 4472794..4473129 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP73_RS21580 (4468579) 4468579..4469349 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QJP73_RS21585 (4469365) 4469365..4470699 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP73_RS21590 (4471074) 4471074..4472645 + 1572 WP_001273763.1 galactarate dehydratase -
QJP73_RS21595 (4472794) 4472794..4473129 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP73_RS21600 (4473129) 4473129..4473593 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP73_RS21605 (4473648) 4473648..4474457 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP73_RS21610 (4474706) 4474706..4475986 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP73_RS21615 (4476009) 4476009..4476482 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP73_RS21620 (4476493) 4476493..4477272 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP73_RS21625 (4477262) 4477262..4478140 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP73_RS21630 (4478158) 4478158..4478592 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T280666 WP_000347251.1 NZ_CP124502:4473129-4473593 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT280666 WP_001296435.1 NZ_CP124502:4472794-4473129 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References