Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3079176..3079678 Replicon chromosome
Accession NZ_CP124502
Organism Escherichia coli strain AVS0970

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QJP73_RS15080 Protein ID WP_000767822.1
Coordinates 3079176..3079430 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJP73_RS15085 Protein ID WP_001259255.1
Coordinates 3079427..3079678 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP73_RS15060 (3075669) 3075669..3077027 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
QJP73_RS15065 (3077017) 3077017..3077079 - 63 WP_010723108.1 membrane protein YoeI -
QJP73_RS15070 (3077294) 3077294..3078223 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP73_RS15075 (3078269) 3078269..3079093 - 825 WP_000754737.1 SDR family oxidoreductase -
QJP73_RS15080 (3079176) 3079176..3079430 - 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP73_RS15085 (3079427) 3079427..3079678 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP73_RS15090 (3079961) 3079961..3080011 + 51 WP_001364200.1 his operon leader peptide -
QJP73_RS15095 (3080157) 3080157..3081056 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP73_RS15100 (3081062) 3081062..3082366 + 1305 WP_001546022.1 histidinol dehydrogenase -
QJP73_RS15105 (3082363) 3082363..3083433 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
QJP73_RS15110 (3083433) 3083433..3084500 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T280662 WP_000767822.1 NZ_CP124502:c3079430-3079176 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT280662 WP_001259255.1 NZ_CP124502:c3079678-3079427 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References