Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 670081..670880 Replicon chromosome
Accession NZ_CP124500
Organism Escherichia coli strain AVS0744

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJB04_RS03275 Protein ID WP_000347251.1
Coordinates 670081..670545 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJB04_RS03280 Protein ID WP_001296435.1
Coordinates 670545..670880 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB04_RS03245 (665082) 665082..665516 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QJB04_RS03250 (665534) 665534..666412 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJB04_RS03255 (666402) 666402..667181 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJB04_RS03260 (667192) 667192..667665 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJB04_RS03265 (667688) 667688..668968 - 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJB04_RS03270 (669217) 669217..670026 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJB04_RS03275 (670081) 670081..670545 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJB04_RS03280 (670545) 670545..670880 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJB04_RS03285 (671029) 671029..672600 - 1572 WP_001273763.1 galactarate dehydratase -
QJB04_RS03290 (672975) 672975..674309 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJB04_RS03295 (674325) 674325..675095 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T280625 WP_000347251.1 NZ_CP124500:c670545-670081 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT280625 WP_001296435.1 NZ_CP124500:c670880-670545 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References