280623

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 253009..254327 Replicon chromosome
Accession NZ_CP124500
Organism Escherichia coli strain AVS0744

Toxin (Protein)


Gene name HipT Uniprot ID F4T5A3
Locus tag QJB04_RS01190 Protein ID WP_001262467.1
Coordinates 253320..254327 (+) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F4T5A4
Locus tag QJB04_RS01185 Protein ID WP_001312177.1
Coordinates 253009..253320 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB04_RS01160 (248541) 248541..249560 + 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -
QJB04_RS01165 (249570) 249570..250472 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
QJB04_RS01170 (250483) 250483..251466 + 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
QJB04_RS01175 (251463) 251463..252476 + 1014 WP_000103572.1 dipeptide ABC transporter ATP-binding subunit DppF -
QJB04_RS01180 (252701) 252701..253024 + 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
QJB04_RS01185 (253009) 253009..253320 + 312 WP_001312177.1 HipA N-terminal domain-containing protein Antitoxin
QJB04_RS01190 (253320) 253320..254327 + 1008 WP_001262467.1 HipA domain-containing protein Toxin
QJB04_RS01195 (254344) 254344..255615 - 1272 WP_001545666.1 amino acid permease -
- (255977) 255977..256042 - 66 NuclAT_27 - -
- (255977) 255977..256042 - 66 NuclAT_27 - -
- (255977) 255977..256042 - 66 NuclAT_27 - -
- (255977) 255977..256042 - 66 NuclAT_27 - -
QJB04_RS01200 (256091) 256091..256198 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- (256460) 256460..256517 - 58 NuclAT_26 - -
- (256460) 256460..256517 - 58 NuclAT_26 - -
- (256460) 256460..256517 - 58 NuclAT_26 - -
- (256460) 256460..256517 - 58 NuclAT_26 - -
QJB04_RS01205 (256574) 256574..256681 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
QJB04_RS01210 (257057) 257057..257164 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
QJB04_RS01215 (257250) 257250..258929 - 1680 Protein_240 cellulose biosynthesis protein BcsG -
QJB04_RS01220 (258926) 258926..259117 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38320.60 Da        Isoelectric Point: 5.5965

>T280623 WP_001262467.1 NZ_CP124500:253320-254327 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11821.47 Da        Isoelectric Point: 6.0609

>AT280623 WP_001312177.1 NZ_CP124500:253009-253320 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K2ZTB5

Antitoxin

Source ID Structure
AlphaFold DB A0A3L3HKE2

References