Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1927724..1928226 Replicon chromosome
Accession NZ_CP124498
Organism Escherichia coli strain AVS0655

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QJP65_RS09065 Protein ID WP_000767822.1
Coordinates 1927972..1928226 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJP65_RS09060 Protein ID WP_001259255.1
Coordinates 1927724..1927975 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP65_RS09035 (1922902) 1922902..1923969 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QJP65_RS09040 (1923969) 1923969..1925039 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
QJP65_RS09045 (1925036) 1925036..1926340 - 1305 WP_001546022.1 histidinol dehydrogenase -
QJP65_RS09050 (1926346) 1926346..1927245 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP65_RS09055 (1927391) 1927391..1927441 - 51 WP_001364200.1 his operon leader peptide -
QJP65_RS09060 (1927724) 1927724..1927975 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP65_RS09065 (1927972) 1927972..1928226 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP65_RS09070 (1928309) 1928309..1929133 + 825 WP_000754737.1 SDR family oxidoreductase -
QJP65_RS09075 (1929179) 1929179..1930108 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP65_RS09080 (1930323) 1930323..1930385 + 63 WP_010723108.1 membrane protein YoeI -
QJP65_RS09085 (1930375) 1930375..1931733 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T280608 WP_000767822.1 NZ_CP124498:1927972-1928226 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT280608 WP_001259255.1 NZ_CP124498:1927724-1927975 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References