Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 253015..254333 Replicon chromosome
Accession NZ_CP124498
Organism Escherichia coli strain AVS0655

Toxin (Protein)


Gene name HipT Uniprot ID F4T5A3
Locus tag QJP65_RS01195 Protein ID WP_001262467.1
Coordinates 253326..254333 (+) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F4T5A4
Locus tag QJP65_RS01190 Protein ID WP_001312177.1
Coordinates 253015..253326 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP65_RS01165 (248547) 248547..249566 + 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -
QJP65_RS01170 (249576) 249576..250478 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
QJP65_RS01175 (250489) 250489..251472 + 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
QJP65_RS01180 (251469) 251469..252482 + 1014 WP_000103572.1 dipeptide ABC transporter ATP-binding subunit DppF -
QJP65_RS01185 (252707) 252707..253030 + 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
QJP65_RS01190 (253015) 253015..253326 + 312 WP_001312177.1 HipA N-terminal domain-containing protein Antitoxin
QJP65_RS01195 (253326) 253326..254333 + 1008 WP_001262467.1 HipA domain-containing protein Toxin
QJP65_RS01200 (254350) 254350..255621 - 1272 WP_001545666.1 amino acid permease -
- (255983) 255983..256048 - 66 NuclAT_27 - -
- (255983) 255983..256048 - 66 NuclAT_27 - -
- (255983) 255983..256048 - 66 NuclAT_27 - -
- (255983) 255983..256048 - 66 NuclAT_27 - -
QJP65_RS01205 (256097) 256097..256204 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- (256466) 256466..256523 - 58 NuclAT_26 - -
- (256466) 256466..256523 - 58 NuclAT_26 - -
- (256466) 256466..256523 - 58 NuclAT_26 - -
- (256466) 256466..256523 - 58 NuclAT_26 - -
QJP65_RS01210 (256580) 256580..256687 + 108 WP_000170748.1 type I toxin-antitoxin system toxin Ldr family protein -
QJP65_RS01215 (257063) 257063..257170 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
QJP65_RS01220 (257256) 257256..258935 - 1680 Protein_241 cellulose biosynthesis protein BcsG -
QJP65_RS01225 (258932) 258932..259123 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38320.60 Da        Isoelectric Point: 5.5965

>T280602 WP_001262467.1 NZ_CP124498:253326-254333 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11821.47 Da        Isoelectric Point: 6.0609

>AT280602 WP_001312177.1 NZ_CP124498:253015-253326 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K2ZTB5

Antitoxin

Source ID Structure
AlphaFold DB A0A3L3HKE2

References