Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1989133..1989635 Replicon chromosome
Accession NZ_CP124495
Organism Escherichia coli strain AVS0662

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QJP57_RS09465 Protein ID WP_000767822.1
Coordinates 1989381..1989635 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJP57_RS09460 Protein ID WP_001259255.1
Coordinates 1989133..1989384 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP57_RS09435 (1984311) 1984311..1985378 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QJP57_RS09440 (1985378) 1985378..1986448 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
QJP57_RS09445 (1986445) 1986445..1987749 - 1305 WP_001546022.1 histidinol dehydrogenase -
QJP57_RS09450 (1987755) 1987755..1988654 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP57_RS09455 (1988800) 1988800..1988850 - 51 WP_001364200.1 his operon leader peptide -
QJP57_RS09460 (1989133) 1989133..1989384 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP57_RS09465 (1989381) 1989381..1989635 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP57_RS09470 (1989718) 1989718..1990542 + 825 WP_000754737.1 SDR family oxidoreductase -
QJP57_RS09475 (1990588) 1990588..1991517 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP57_RS09480 (1991732) 1991732..1991794 + 63 WP_010723108.1 membrane protein YoeI -
QJP57_RS09485 (1991784) 1991784..1993142 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T280581 WP_000767822.1 NZ_CP124495:1989381-1989635 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT280581 WP_001259255.1 NZ_CP124495:1989133-1989384 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References