Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1860940..1861442 Replicon chromosome
Accession NZ_CP124492
Organism Escherichia coli strain AVS0225

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QJA99_RS08755 Protein ID WP_000767822.1
Coordinates 1861188..1861442 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJA99_RS08750 Protein ID WP_001259255.1
Coordinates 1860940..1861191 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJA99_RS08725 (1856118) 1856118..1857185 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QJA99_RS08730 (1857185) 1857185..1858255 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
QJA99_RS08735 (1858252) 1858252..1859556 - 1305 WP_001546022.1 histidinol dehydrogenase -
QJA99_RS08740 (1859562) 1859562..1860461 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJA99_RS08745 (1860607) 1860607..1860657 - 51 WP_001364200.1 his operon leader peptide -
QJA99_RS08750 (1860940) 1860940..1861191 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJA99_RS08755 (1861188) 1861188..1861442 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJA99_RS08760 (1861525) 1861525..1862349 + 825 WP_000754737.1 SDR family oxidoreductase -
QJA99_RS08765 (1862395) 1862395..1863324 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJA99_RS08770 (1863539) 1863539..1863601 + 63 WP_010723108.1 membrane protein YoeI -
QJA99_RS08775 (1863591) 1863591..1864949 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T280561 WP_000767822.1 NZ_CP124492:1861188-1861442 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT280561 WP_001259255.1 NZ_CP124492:1860940-1861191 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References