Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1892718..1893220 Replicon chromosome
Accession NZ_CP124490
Organism Escherichia coli strain AVS0456

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag QJP91_RS08915 Protein ID WP_000767819.1
Coordinates 1892966..1893220 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag QJP91_RS08910 Protein ID WP_001259253.1
Coordinates 1892718..1892969 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP91_RS08885 (1887896) 1887896..1888963 - 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QJP91_RS08890 (1888963) 1888963..1890033 - 1071 WP_000108967.1 histidinol-phosphate transaminase -
QJP91_RS08895 (1890030) 1890030..1891334 - 1305 WP_001296211.1 histidinol dehydrogenase -
QJP91_RS08900 (1891340) 1891340..1892239 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP91_RS08905 (1892385) 1892385..1892435 - 51 WP_001364200.1 his operon leader peptide -
QJP91_RS08910 (1892718) 1892718..1892969 + 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP91_RS08915 (1892966) 1892966..1893220 + 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP91_RS08920 (1893303) 1893303..1894127 + 825 WP_000754737.1 SDR family oxidoreductase -
QJP91_RS08925 (1894173) 1894173..1895102 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP91_RS08930 (1895317) 1895317..1895379 + 63 WP_010723108.1 membrane protein YoeI -
QJP91_RS08935 (1895369) 1895369..1896727 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -
QJP91_RS08940 (1896944) 1896944..1897402 + 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1896944..1897402 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T280542 WP_000767819.1 NZ_CP124490:1892966-1893220 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT280542 WP_001259253.1 NZ_CP124490:1892718-1892969 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References