28052

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2852438..2852945 Replicon chromosome
Accession NC_018142
Organism Propionibacterium propionicum F0230a

Toxin (Protein)


Gene name yoeB Uniprot ID A0A4V1GCM1
Locus tag HMPREF9154_RS12765 Protein ID WP_014847590.1
Coordinates 2852438..2852692 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A3N4D924
Locus tag HMPREF9154_RS12770 Protein ID WP_014847591.1
Coordinates 2852694..2852945 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMPREF9154_RS12740 2848678..2849151 - 474 WP_014847587.1 GNAT family N-acetyltransferase -
HMPREF9154_RS16470 2849256..2850041 - 786 WP_051015054.1 MFS transporter -
HMPREF9154_RS16475 2850025..2850657 - 633 Protein_2536 MFS transporter -
HMPREF9154_RS12750 2850711..2851535 + 825 WP_014847588.1 class I SAM-dependent methyltransferase -
HMPREF9154_RS12755 2851543..2851779 - 237 WP_014847589.1 antitoxin -
HMPREF9154_RS15775 2852098..2852379 + 282 WP_123824087.1 hypothetical protein -
HMPREF9154_RS12765 2852438..2852692 - 255 WP_014847590.1 Txe/YoeB family addiction module toxin Toxin
HMPREF9154_RS12770 2852694..2852945 - 252 WP_014847591.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HMPREF9154_RS12775 2853123..2853707 - 585 WP_014847592.1 TetR family transcriptional regulator -
HMPREF9154_RS12780 2853778..2855007 + 1230 WP_014847593.1 MFS transporter -
HMPREF9154_RS12785 2854994..2855947 - 954 WP_014847594.1 NmrA/HSCARG family protein -
HMPREF9154_RS12790 2856069..2856452 + 384 WP_014847595.1 helix-turn-helix transcriptional regulator -
HMPREF9154_RS12795 2856528..2857565 + 1038 WP_051015057.1 DUF2330 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-69)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9826.09 Da        Isoelectric Point: 6.4548

>T28052 WP_014847590.1 NC_018142:c2852692-2852438 [Arachnia propionica F0230a]
VRLAWDPSAWEDYTYWQAADSRILKRINALIDTCLRDPFGGIGKPEQLRYGATGAWSRRITEEHRLVYLVDGDDLVILQA
RYHY

Download         Length: 255 bp

>T28052 NC_018142:c2852692-2852438 [Arachnia propionica F0230a]
GTGCGCCTGGCGTGGGATCCCTCGGCCTGGGAGGATTACACGTACTGGCAGGCCGCGGATAGCCGGATTCTCAAGCGGAT
CAACGCGCTCATCGACACCTGCCTCCGCGATCCCTTCGGTGGGATCGGGAAACCTGAACAACTCAGGTATGGGGCAACGG
GGGCTTGGTCGCGGCGCATCACGGAGGAGCACCGGCTCGTGTATCTCGTCGACGGCGACGACCTGGTGATCCTCCAGGCC
CGGTACCACTACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9497.50 Da        Isoelectric Point: 4.6794

>AT28052 WP_014847591.1 NC_018142:c2852945-2852694 [Arachnia propionica F0230a]
VSISASEARRTLFPLIEQVNDDRTAVEIVSRKGNAVLMSADEYAAWQETAYLFRSPANARRLLDAYERAREGRSEEHDLI
RED

Download         Length: 252 bp

>AT28052 NC_018142:c2852945-2852694 [Arachnia propionica F0230a]
GTGTCCATCAGCGCCAGCGAGGCCCGCAGGACGTTGTTCCCGCTCATCGAGCAGGTCAACGACGATCGCACTGCCGTCGA
GATCGTTTCCCGCAAGGGGAACGCCGTTCTCATGTCCGCCGATGAATACGCCGCGTGGCAGGAGACGGCCTACCTGTTCC
GTTCCCCCGCCAATGCCCGAAGGCTGCTCGACGCCTACGAGAGGGCCCGGGAAGGACGGAGCGAGGAACACGATCTCATC
CGGGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V1GCM1

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4D924

References