Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1948477..1948979 Replicon chromosome
Accession NZ_CP124487
Organism Escherichia coli strain AVS0542

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QJP68_RS09200 Protein ID WP_000767822.1
Coordinates 1948725..1948979 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJP68_RS09195 Protein ID WP_001259255.1
Coordinates 1948477..1948728 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP68_RS09170 (1943655) 1943655..1944722 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QJP68_RS09175 (1944722) 1944722..1945792 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
QJP68_RS09180 (1945789) 1945789..1947093 - 1305 WP_001546022.1 histidinol dehydrogenase -
QJP68_RS09185 (1947099) 1947099..1947998 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP68_RS09190 (1948144) 1948144..1948194 - 51 WP_001364200.1 his operon leader peptide -
QJP68_RS09195 (1948477) 1948477..1948728 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP68_RS09200 (1948725) 1948725..1948979 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP68_RS09205 (1949062) 1949062..1949886 + 825 WP_000754737.1 SDR family oxidoreductase -
QJP68_RS09210 (1949932) 1949932..1950861 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP68_RS09215 (1951076) 1951076..1951138 + 63 WP_010723108.1 membrane protein YoeI -
QJP68_RS09220 (1951128) 1951128..1952486 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T280516 WP_000767822.1 NZ_CP124487:1948725-1948979 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT280516 WP_001259255.1 NZ_CP124487:1948477-1948728 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References