Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1914317..1914819 Replicon chromosome
Accession NZ_CP124483
Organism Escherichia coli strain AVS0575

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QJP96_RS08995 Protein ID WP_000767822.1
Coordinates 1914565..1914819 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJP96_RS08990 Protein ID WP_001259255.1
Coordinates 1914317..1914568 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP96_RS08965 (1909495) 1909495..1910562 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QJP96_RS08970 (1910562) 1910562..1911632 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
QJP96_RS08975 (1911629) 1911629..1912933 - 1305 WP_001546022.1 histidinol dehydrogenase -
QJP96_RS08980 (1912939) 1912939..1913838 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP96_RS08985 (1913984) 1913984..1914034 - 51 WP_001364200.1 his operon leader peptide -
QJP96_RS08990 (1914317) 1914317..1914568 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP96_RS08995 (1914565) 1914565..1914819 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP96_RS09000 (1914902) 1914902..1915726 + 825 WP_000754737.1 SDR family oxidoreductase -
QJP96_RS09005 (1915772) 1915772..1916701 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP96_RS09010 (1916916) 1916916..1916978 + 63 WP_010723108.1 membrane protein YoeI -
QJP96_RS09015 (1916968) 1916968..1918326 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T280495 WP_000767822.1 NZ_CP124483:1914565-1914819 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT280495 WP_001259255.1 NZ_CP124483:1914317-1914568 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References