Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 659396..660195 Replicon chromosome
Accession NZ_CP124483
Organism Escherichia coli strain AVS0575

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP96_RS03230 Protein ID WP_000347251.1
Coordinates 659396..659860 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP96_RS03235 Protein ID WP_001296435.1
Coordinates 659860..660195 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP96_RS03200 (654397) 654397..654831 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QJP96_RS03205 (654849) 654849..655727 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP96_RS03210 (655717) 655717..656496 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP96_RS03215 (656507) 656507..656980 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP96_RS03220 (657003) 657003..658283 - 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP96_RS03225 (658532) 658532..659341 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP96_RS03230 (659396) 659396..659860 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP96_RS03235 (659860) 659860..660195 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP96_RS03240 (660344) 660344..661915 - 1572 WP_001273763.1 galactarate dehydratase -
QJP96_RS03245 (662290) 662290..663624 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP96_RS03250 (663640) 663640..664410 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T280491 WP_000347251.1 NZ_CP124483:c659860-659396 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT280491 WP_001296435.1 NZ_CP124483:c660195-659860 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References