280489

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 242324..243642 Replicon chromosome
Accession NZ_CP124483
Organism Escherichia coli strain AVS0575

Toxin (Protein)


Gene name HipT Uniprot ID F4T5A3
Locus tag QJP96_RS01145 Protein ID WP_001262467.1
Coordinates 242635..243642 (+) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F4T5A4
Locus tag QJP96_RS01140 Protein ID WP_001312177.1
Coordinates 242324..242635 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP96_RS01115 (237856) 237856..238875 + 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -
QJP96_RS01120 (238885) 238885..239787 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
QJP96_RS01125 (239798) 239798..240781 + 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
QJP96_RS01130 (240778) 240778..241791 + 1014 WP_000103572.1 dipeptide ABC transporter ATP-binding subunit DppF -
QJP96_RS01135 (242016) 242016..242339 + 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
QJP96_RS01140 (242324) 242324..242635 + 312 WP_001312177.1 HipA N-terminal domain-containing protein Antitoxin
QJP96_RS01145 (242635) 242635..243642 + 1008 WP_001262467.1 HipA domain-containing protein Toxin
QJP96_RS01150 (243659) 243659..244930 - 1272 WP_001545666.1 amino acid permease -
- (245292) 245292..245357 - 66 NuclAT_27 - -
- (245292) 245292..245357 - 66 NuclAT_27 - -
- (245292) 245292..245357 - 66 NuclAT_27 - -
- (245292) 245292..245357 - 66 NuclAT_27 - -
QJP96_RS01155 (245406) 245406..245513 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- (245775) 245775..245832 - 58 NuclAT_26 - -
- (245775) 245775..245832 - 58 NuclAT_26 - -
- (245775) 245775..245832 - 58 NuclAT_26 - -
- (245775) 245775..245832 - 58 NuclAT_26 - -
QJP96_RS01160 (245889) 245889..245996 + 108 WP_000170748.1 type I toxin-antitoxin system toxin Ldr family protein -
QJP96_RS01165 (246372) 246372..246479 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
QJP96_RS01170 (246565) 246565..248244 - 1680 Protein_231 cellulose biosynthesis protein BcsG -
QJP96_RS01175 (248241) 248241..248432 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38320.60 Da        Isoelectric Point: 5.5965

>T280489 WP_001262467.1 NZ_CP124483:242635-243642 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11821.47 Da        Isoelectric Point: 6.0609

>AT280489 WP_001312177.1 NZ_CP124483:242324-242635 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K2ZTB5

Antitoxin

Source ID Structure
AlphaFold DB A0A3L3HKE2

References