Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4385578..4386377 Replicon chromosome
Accession NZ_CP124481
Organism Escherichia coli strain AVS0756

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP55_RS21320 Protein ID WP_000347251.1
Coordinates 4385913..4386377 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP55_RS21315 Protein ID WP_001296435.1
Coordinates 4385578..4385913 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP55_RS21300 (4381363) 4381363..4382133 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QJP55_RS21305 (4382149) 4382149..4383483 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP55_RS21310 (4383858) 4383858..4385429 + 1572 WP_001273763.1 galactarate dehydratase -
QJP55_RS21315 (4385578) 4385578..4385913 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP55_RS21320 (4385913) 4385913..4386377 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP55_RS21325 (4386432) 4386432..4387241 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP55_RS21330 (4387490) 4387490..4388770 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP55_RS21335 (4388793) 4388793..4389266 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP55_RS21340 (4389277) 4389277..4390056 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP55_RS21345 (4390046) 4390046..4390924 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP55_RS21350 (4390942) 4390942..4391376 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T280481 WP_000347251.1 NZ_CP124481:4385913-4386377 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT280481 WP_001296435.1 NZ_CP124481:4385578-4385913 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References