Detailed information of TA system TA028048

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 546368..546887
• Replicon: chromosome
• Accession: NC_018142
• Organism: Propionibacterium propionicum F0230a

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A3N4CWJ0
• Locus tag: HMPREF9154_RS02475
• Protein ID: WP_014845635.1
• Coordinates: 546368..546628 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HMPREF9154_RS02480
• Protein ID: WP_014845636.1
• Coordinates: 546630..546887 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMPREF9154_RS02455	542095..542973	+	879	WP_014845630.1	neutral zinc metallopeptidase	-
HMPREF9154_RS02460	543044..544207	+	1164	WP_198341740.1	4-hydroxybutyrate CoA-transferase	-
HMPREF9154_RS02465	544422..545405	-	984	WP_123823886.1	hypothetical protein	-
HMPREF9154_RS02470	545501..546154	-	654	WP_014845634.1	peptide-methionine (S)-S-oxide reductase MsrA	-
HMPREF9154_RS02475	546368..546628	-	261	WP_014845635.1	Txe/YoeB family addiction module toxin	Toxin
HMPREF9154_RS02480	546630..546887	-	258	WP_014845636.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HMPREF9154_RS02485	547240..549171	+	1932	WP_041696138.1	serine hydrolase	-
HMPREF9154_RS15405	549238..550281	+	1044	WP_051014908.1	alpha/beta hydrolase	-
HMPREF9154_RS02495	550278..551435	+	1158	WP_014845639.1	two-component sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-72)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10590.93 Da
• Isoelectric Point: 8.4729

>T28048 WP_014845635.1 NC_018142:c546628-546368 [Arachnia propionica F0230a]
MRICWADEAWEDYLWWQTQDRRTLKRINSLIRDIARNGNEELGKPEALRYQLSGYWSRRITEEHRLVYRITDTEVQIAAC
RYHYGR

Nucleotide

• Length: 261 bp

>T28048 NC_018142:c546628-546368 [Arachnia propionica F0230a]
ATGCGGATCTGCTGGGCCGACGAAGCGTGGGAGGACTACCTCTGGTGGCAAACCCAGGACCGCCGGACCCTCAAGAGAAT
CAACTCCCTGATCCGGGACATCGCTCGCAACGGAAACGAGGAACTGGGCAAACCGGAGGCGCTGCGATACCAACTCTCCG
GCTACTGGTCCCGGCGTATCACTGAGGAGCATCGGCTGGTCTACCGAATCACCGACACCGAGGTCCAGATTGCCGCATGC
CGGTACCACTATGGCCGCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9609.68 Da
• Isoelectric Point: 4.4777

>AT28048 WP_014845636.1 NC_018142:c546887-546630 [Arachnia propionica F0230a]
VKTMSYTESRANYAAVLDEVVNNREEIVITRAGHEPVVIVSLEEYQSLRETAYLLRSPANAQRLASAMEQLDRNDGIPHD
LLDDH

Nucleotide

• Length: 258 bp

>AT28048 NC_018142:c546887-546630 [Arachnia propionica F0230a]
GTGAAGACCATGTCGTACACCGAGTCCCGAGCCAACTACGCGGCGGTCCTCGACGAGGTCGTGAACAATCGCGAGGAGAT
CGTCATCACCCGGGCAGGACACGAACCCGTCGTGATCGTCTCCCTGGAGGAGTACCAGTCCCTTCGCGAGACCGCCTACC
TGTTGCGTTCGCCCGCCAACGCCCAGCGGCTGGCCAGCGCCATGGAACAGCTCGACAGGAACGACGGCATCCCGCACGAC
CTCCTCGACGACCACTGA

Structures

Toxin

• AlphaFold DB: A0A3N4CWJ0