280476

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3079412..3079914 Replicon chromosome
Accession NZ_CP124481
Organism Escherichia coli strain AVS0756

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QJP55_RS15195 Protein ID WP_000767822.1
Coordinates 3079412..3079666 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJP55_RS15200 Protein ID WP_001259255.1
Coordinates 3079663..3079914 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP55_RS15175 (3075905) 3075905..3077263 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
QJP55_RS15180 (3077253) 3077253..3077315 - 63 WP_010723108.1 membrane protein YoeI -
QJP55_RS15185 (3077530) 3077530..3078459 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP55_RS15190 (3078505) 3078505..3079329 - 825 WP_000754737.1 SDR family oxidoreductase -
QJP55_RS15195 (3079412) 3079412..3079666 - 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP55_RS15200 (3079663) 3079663..3079914 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP55_RS15205 (3080197) 3080197..3080247 + 51 WP_001364200.1 his operon leader peptide -
QJP55_RS15210 (3080393) 3080393..3081292 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP55_RS15215 (3081298) 3081298..3082602 + 1305 WP_001546022.1 histidinol dehydrogenase -
QJP55_RS15220 (3082599) 3082599..3083669 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
QJP55_RS15225 (3083669) 3083669..3084736 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T280476 WP_000767822.1 NZ_CP124481:c3079666-3079412 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT280476 WP_001259255.1 NZ_CP124481:c3079914-3079663 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References