28045

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2769880..2771117 Replicon chromosome
Accession NC_018140
Organism Legionella pneumophila subsp. pneumophila

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag LPV_RS12345 Protein ID WP_027268299.1
Coordinates 2770185..2771117 (+) Length 311 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag LPV_RS12340 Protein ID WP_027268300.1
Coordinates 2769880..2770188 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPV_RS12310 2765297..2765965 - 669 WP_014844529.1 hypothetical protein -
LPV_RS12315 2765968..2766540 - 573 WP_014844530.1 hypothetical protein -
LPV_RS16320 2766954..2767228 - 275 Protein_2431 hypothetical protein -
LPV_RS12325 2767632..2768105 + 474 WP_014844532.1 hypothetical protein -
LPV_RS12330 2768295..2769212 + 918 WP_014844533.1 LysR family transcriptional regulator -
LPV_RS12335 2769656..2769883 + 228 WP_013101792.1 helix-turn-helix transcriptional regulator -
LPV_RS12340 2769880..2770188 + 309 WP_027268300.1 HipA N-terminal domain-containing protein Antitoxin
LPV_RS12345 2770185..2771117 + 933 WP_027268299.1 HipA domain-containing protein Toxin
LPV_RS12350 2771246..2773813 + 2568 WP_014844535.1 magnesium-translocating P-type ATPase -
LPV_RS12355 2773848..2774792 + 945 WP_014844536.1 flippase-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-279)

Antitoxin

HipA, N-terminal subdomain 1

(3-98)


Sequences

Toxin        


Download         Length: 311 a.a.        Molecular weight: 35808.52 Da        Isoelectric Point: 9.5986

>T28045 WP_027268299.1 NC_018140:2770185-2771117 [Legionella pneumophila subsp. pneumophila]
MKRCPITYEKISDQENYSQRGLRLLSPQLKNLSPLDLSADEQRREAIARVGKMSIQGVQKKLSAKLQIKEGCFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAIIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITRDRKISISPAYDLLNSTIAQKNTKEEIALPLKG
KKNNLTKSDFLNYFAVEKLGLNQKVINGIAQEFHQAIPEWRELIGFSFLSQPMQEKYLQLLDQRCKRLNF

Download         Length: 933 bp

>T28045 NC_018140:2770185-2771117 [Legionella pneumophila subsp. pneumophila]
ATGAAACGCTGCCCCATTACTTATGAAAAAATCAGTGACCAAGAAAACTATTCACAACGTGGATTGCGCTTGCTTTCTCC
TCAATTAAAAAACCTGAGCCCATTAGATTTAAGTGCTGATGAGCAGCGTCGGGAAGCAATTGCTCGAGTAGGAAAGATGT
CTATTCAAGGTGTCCAAAAAAAACTAAGCGCAAAACTACAGATTAAAGAGGGATGTTTTGAAATCGTGGATCAAAATGGC
CACTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTACCAGAAAACGAAGCCATTACCATGACCCTTGCAAAAAC
CATTGGCCTTGAAGTGCCTGTTCATGGTTTAGTGTACTCTAAAGATAACAGTTTGACTTACTTCATTAAACGGTTTGATA
GAATAGGCCATAATAAAAAATTAGCTTTAGAAGATTTTGCACAGCTATCGGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTGATTGCAATCATAGAGCAGTTTTGCACGTTCCCCAAAATTGAATTCGTGAAATTATTTAAGTTGAC
ATTGTTTAACTTCCTGGTCGGCAATGAAGACATGCACCTAAAAAATTTTTCTCTAATTACCAGGGATAGAAAAATTTCCA
TATCACCAGCATACGATTTACTTAACTCAACTATCGCTCAAAAAAACACAAAAGAAGAAATCGCATTGCCCCTCAAAGGG
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAACTATTTTGCCGTTGAAAAATTAGGATTAAATCAGAAGGTCATAAA
TGGGATCGCACAAGAGTTTCATCAGGCAATACCAGAATGGCGAGAGTTGATTGGTTTCAGTTTTTTATCTCAACCGATGC
AGGAAAAATATCTCCAATTGCTCGATCAACGTTGCAAGAGATTAAATTTTTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11586.38 Da        Isoelectric Point: 4.5859

>AT28045 WP_027268300.1 NC_018140:2769880-2770188 [Legionella pneumophila subsp. pneumophila]
MRKAYVSVNGIKAGILEELQSGKYQFSYFDDYHGAPVSLTMPLTNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEEIR

Download         Length: 309 bp

>AT28045 NC_018140:2769880-2770188 [Legionella pneumophila subsp. pneumophila]
ATGAGAAAAGCATACGTATCAGTGAATGGCATCAAGGCTGGAATATTAGAAGAATTACAAAGCGGAAAATATCAATTCAG
TTACTTTGATGATTATCACGGGGCACCTGTTTCTCTCACAATGCCGTTAACCAATAAGGTCTATGATTTTGATGTATTTC
CCCCTTTTTTCGAAGGGTTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGCAAATATAAAATCGATAAAAATGAT
TATTTTGGCCAATTGATACTAGTTGGCCAGGATGTCGTAGGCGCAGTGACTATTGAGGAAATAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References