Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1899655..1900157 Replicon chromosome
Accession NZ_CP124475
Organism Escherichia coli strain AVS0969

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QJP78_RS09025 Protein ID WP_000767822.1
Coordinates 1899903..1900157 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJP78_RS09020 Protein ID WP_001259255.1
Coordinates 1899655..1899906 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP78_RS08995 (1894833) 1894833..1895900 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QJP78_RS09000 (1895900) 1895900..1896970 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
QJP78_RS09005 (1896967) 1896967..1898271 - 1305 WP_001546022.1 histidinol dehydrogenase -
QJP78_RS09010 (1898277) 1898277..1899176 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP78_RS09015 (1899322) 1899322..1899372 - 51 WP_001364200.1 his operon leader peptide -
QJP78_RS09020 (1899655) 1899655..1899906 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP78_RS09025 (1899903) 1899903..1900157 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP78_RS09030 (1900240) 1900240..1901064 + 825 WP_000754737.1 SDR family oxidoreductase -
QJP78_RS09035 (1901110) 1901110..1902039 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP78_RS09040 (1902254) 1902254..1902316 + 63 WP_010723108.1 membrane protein YoeI -
QJP78_RS09045 (1902306) 1902306..1903664 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T280431 WP_000767822.1 NZ_CP124475:1899903-1900157 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT280431 WP_001259255.1 NZ_CP124475:1899655-1899906 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References