Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1883111..1883613 Replicon chromosome
Accession NZ_CP124471
Organism Escherichia coli strain AVS0973

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QJP95_RS08835 Protein ID WP_000767822.1
Coordinates 1883359..1883613 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJP95_RS08830 Protein ID WP_001259255.1
Coordinates 1883111..1883362 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP95_RS08805 (1878289) 1878289..1879356 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QJP95_RS08810 (1879356) 1879356..1880426 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
QJP95_RS08815 (1880423) 1880423..1881727 - 1305 WP_001546022.1 histidinol dehydrogenase -
QJP95_RS08820 (1881733) 1881733..1882632 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP95_RS08825 (1882778) 1882778..1882828 - 51 WP_001364200.1 his operon leader peptide -
QJP95_RS08830 (1883111) 1883111..1883362 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP95_RS08835 (1883359) 1883359..1883613 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP95_RS08840 (1883696) 1883696..1884520 + 825 WP_000754737.1 SDR family oxidoreductase -
QJP95_RS08845 (1884566) 1884566..1885495 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP95_RS08850 (1885710) 1885710..1885772 + 63 WP_010723108.1 membrane protein YoeI -
QJP95_RS08855 (1885762) 1885762..1887120 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T280406 WP_000767822.1 NZ_CP124471:1883359-1883613 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT280406 WP_001259255.1 NZ_CP124471:1883111-1883362 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References