Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4632440..4633042 Replicon chromosome
Accession NZ_CP124467
Organism Escherichia coli strain AVS0747

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QJB08_RS22450 Protein ID WP_000897302.1
Coordinates 4632731..4633042 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJB08_RS22445 Protein ID WP_000356397.1
Coordinates 4632440..4632730 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB08_RS22415 (4627747) 4627747..4628676 + 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -
QJB08_RS22420 (4628858) 4628858..4629100 - 243 WP_001068514.1 CopG family transcriptional regulator -
QJB08_RS22425 (4629390) 4629390..4630238 + 849 WP_001038650.1 hypothetical protein -
QJB08_RS22430 (4630263) 4630263..4631003 + 741 WP_000608806.1 hypothetical protein -
QJB08_RS22435 (4631188) 4631188..4631406 - 219 WP_001251293.1 CopG family transcriptional regulator -
QJB08_RS22440 (4631803) 4631803..4632081 - 279 WP_001296612.1 hypothetical protein -
QJB08_RS22445 (4632440) 4632440..4632730 - 291 WP_000356397.1 NadS family protein Antitoxin
QJB08_RS22450 (4632731) 4632731..4633042 - 312 WP_000897302.1 hypothetical protein Toxin
QJB08_RS22455 (4633271) 4633271..4634179 + 909 WP_001385591.1 alpha/beta hydrolase -
QJB08_RS22460 (4634243) 4634243..4635184 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QJB08_RS22465 (4635229) 4635229..4635666 - 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QJB08_RS22470 (4635663) 4635663..4636535 - 873 WP_000920762.1 virulence factor BrkB family protein -
QJB08_RS22475 (4636529) 4636529..4637128 - 600 WP_001296610.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4629390..4639692 10302


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T280397 WP_000897302.1 NZ_CP124467:c4633042-4632731 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT280397 WP_000356397.1 NZ_CP124467:c4632730-4632440 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References