Detailed information of TA system TA028039

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 1112315..1113168
• Replicon: chromosome
• Accession: NC_018139
• Organism: Legionella pneumophila subsp. pneumophila

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: LPO_RS05040
• Protein ID: WP_014841322.1
• Coordinates: 1112315..1112821 (-)
• Length: 169 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: -
• Locus tag: LPO_RS05045
• Protein ID: WP_014841323.1
• Coordinates: 1112821..1113168 (-)
• Length: 116 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPO_RS05020	1107612..1107884	+	273	WP_011215181.1	helix-turn-helix domain-containing protein	-
LPO_RS05025	1107959..1109710	+	1752	WP_041174118.1	DUF927 domain-containing protein	-
LPO_RS05030	1109833..1110642	-	810	WP_014841319.1	integrase domain-containing protein	-
LPO_RS05035	1111323..1112171	-	849	WP_041174041.1	hypothetical protein	-
LPO_RS05040	1112315..1112821	-	507	WP_014841322.1	type II toxin-antitoxin system YhaV family toxin	Toxin
LPO_RS05045	1112821..1113168	-	348	WP_014841323.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
LPO_RS05050	1113241..1114488	-	1248	WP_014841324.1	tyrosine-type recombinase/integrase	-
LPO_RS05055	1114934..1116541	+	1608	Protein_981	murein biosynthesis integral membrane protein MurJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (14-150)

Antitoxin

• PrlF antitoxin (8-105)

Sequences

Toxin

Protein

• Length: 169 a.a.
• Molecular weight: 19410.02 Da
• Isoelectric Point: 9.6566

>T28039 WP_014841322.1 NC_018139:c1112821-1112315 [Legionella pneumophila subsp. pneumophila]
MGDNSIITINGWAILCHPLFLQQVEALANEVENAKQKDPSNFHTRSSTKKLAAIAKLAFEKIPNDPAATEFRQGSTLGNN
HKHWFRAKFFQQYRLFFRFHQESKIIIYAWVNDDSSKRAYESKADAYHIFRKMLESGHPPDNWDELLKEANNPTLMKKLT
TSLDALRS

Nucleotide

• Length: 507 bp

>T28039 NC_018139:c1112821-1112315 [Legionella pneumophila subsp. pneumophila]
ATGGGCGATAATTCAATAATAACAATAAATGGTTGGGCTATTTTATGTCATCCTCTTTTTTTGCAACAAGTAGAGGCACT
AGCTAATGAGGTAGAAAATGCAAAACAGAAGGACCCTTCAAATTTCCATACACGAAGCTCGACAAAAAAATTAGCCGCCA
TTGCTAAATTAGCTTTTGAAAAAATTCCAAACGATCCTGCAGCTACAGAATTTCGACAAGGCTCAACATTAGGAAATAAC
CACAAACATTGGTTTCGAGCTAAATTTTTTCAGCAATATCGATTATTTTTTAGATTTCATCAAGAAAGTAAAATAATTAT
TTATGCTTGGGTTAATGATGACAGCTCTAAAAGAGCATACGAGAGCAAGGCGGATGCTTATCATATTTTTCGAAAGATGC
TTGAAAGTGGACATCCTCCAGATAATTGGGATGAATTACTCAAAGAGGCAAATAACCCTACATTAATGAAAAAATTAACA
ACCAGCCTGGATGCTTTGAGAAGTTAA

Antitoxin

Protein

• Length: 116 a.a.
• Molecular weight: 13187.81 Da
• Isoelectric Point: 4.5348

>AT28039 WP_014841323.1 NC_018139:c1113168-1112821 [Legionella pneumophila subsp. pneumophila]
MARLLQTESTLTDRYQTTVPDAVRKALHLGKRDKIRYTVQSDGHVLMTRAEEEEDPVIAEFLNFIAKDIQNNPKNLTTIN
QDLVTRINSLVANVEVNLDEPLPEDEELTENRVTR

Nucleotide

• Length: 348 bp

>AT28039 NC_018139:c1113168-1112821 [Legionella pneumophila subsp. pneumophila]
ATGGCTAGATTACTACAAACCGAATCCACCCTCACAGATCGTTATCAAACAACTGTACCAGATGCTGTGAGAAAAGCCCT
GCATCTAGGAAAAAGAGATAAAATTCGATACACCGTTCAATCTGACGGTCATGTTCTTATGACTCGAGCAGAGGAAGAGG
AAGATCCAGTAATTGCTGAATTTTTGAATTTCATTGCTAAAGACATTCAAAATAACCCAAAAAATCTGACAACTATAAAT
CAGGATTTAGTAACTCGCATCAACTCTTTAGTTGCAAATGTTGAAGTCAACTTAGATGAACCTTTACCCGAGGATGAAGA
ATTAACTGAAAACAGAGTAACTCGCTAA