Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1865309..1865811 Replicon chromosome
Accession NZ_CP124467
Organism Escherichia coli strain AVS0747

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7A2Z7A8
Locus tag QJB08_RS08865 Protein ID WP_024705227.1
Coordinates 1865557..1865811 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJB08_RS08860 Protein ID WP_001259255.1
Coordinates 1865309..1865560 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB08_RS08835 (1860487) 1860487..1861554 - 1068 WP_000080128.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QJB08_RS08840 (1861554) 1861554..1862624 - 1071 WP_061157916.1 histidinol-phosphate transaminase -
QJB08_RS08845 (1862621) 1862621..1863925 - 1305 WP_061157915.1 histidinol dehydrogenase -
QJB08_RS08850 (1863931) 1863931..1864830 - 900 WP_000131756.1 ATP phosphoribosyltransferase -
QJB08_RS08855 (1864976) 1864976..1865026 - 51 WP_001364200.1 his operon leader peptide -
QJB08_RS08860 (1865309) 1865309..1865560 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJB08_RS08865 (1865557) 1865557..1865811 + 255 WP_024705227.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJB08_RS08870 (1865894) 1865894..1866718 + 825 WP_000754737.1 SDR family oxidoreductase -
QJB08_RS08875 (1866764) 1866764..1867693 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJB08_RS08880 (1867908) 1867908..1867970 + 63 WP_010723108.1 membrane protein YoeI -
QJB08_RS08885 (1867960) 1867960..1869318 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10173.54 Da        Isoelectric Point: 8.0353

>T280385 WP_024705227.1 NZ_CP124467:1865557-1865811 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPESLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT280385 WP_001259255.1 NZ_CP124467:1865309-1865560 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7A2Z7A8

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References