Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 5993555..5994205 | Replicon | chromosome |
Accession | NC_018106 | ||
Organism | Klebsiella oxytoca E718 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A0H3H3K0 |
Locus tag | A225_RS28010 | Protein ID | WP_014227314.1 |
Coordinates | 5993864..5994205 (-) | Length | 114 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A0H3H3Q5 |
Locus tag | A225_RS28005 | Protein ID | WP_014227313.1 |
Coordinates | 5993555..5993854 (-) | Length | 100 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A225_RS27985 | 5989440..5990159 | - | 720 | WP_014839839.1 | phosphonate utilization transcriptional regulator PhnR | - |
A225_RS27990 | 5990300..5991403 | + | 1104 | WP_042934427.1 | 2-aminoethylphosphonate--pyruvate transaminase | - |
A225_RS27995 | 5991413..5992222 | + | 810 | WP_004855618.1 | phosphonoacetaldehyde hydrolase | - |
A225_RS28000 | 5992255..5993436 | - | 1182 | WP_014839841.1 | purine ribonucleoside efflux pump NepI | - |
A225_RS28005 | 5993555..5993854 | - | 300 | WP_014227313.1 | helix-turn-helix transcriptional regulator | Antitoxin |
A225_RS28010 | 5993864..5994205 | - | 342 | WP_014227314.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
A225_RS28015 | 5994456..5994908 | - | 453 | WP_014839842.1 | DUF1198 domain-containing protein | - |
A225_RS28020 | 5995086..5996477 | - | 1392 | WP_004107098.1 | hexose-6-phosphate:phosphate antiporter | - |
A225_RS28025 | 5996623..5997942 | - | 1320 | WP_014227316.1 | MFS transporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 13110.00 Da Isoelectric Point: 5.7545
>T28036 WP_014227314.1 NC_018106:c5994205-5993864 [Klebsiella michiganensis E718]
MWDVETTEVFDKWFEAQTEALKEDMLAAMVILSEYGPRLGRPFADTVNDSAFSNMKELRIQHQGRPIRAFFVFDPSRCGI
VLCAGDKTGLNEKRFYKDMIKLADAEYRKHLNQ
MWDVETTEVFDKWFEAQTEALKEDMLAAMVILSEYGPRLGRPFADTVNDSAFSNMKELRIQHQGRPIRAFFVFDPSRCGI
VLCAGDKTGLNEKRFYKDMIKLADAEYRKHLNQ
Download Length: 342 bp
>T28036 NC_018106:c5994205-5993864 [Klebsiella michiganensis E718]
ATGTGGGATGTTGAAACAACGGAGGTTTTTGACAAGTGGTTTGAGGCGCAGACCGAAGCGCTCAAAGAGGATATGCTCGC
CGCAATGGTGATCTTATCCGAGTATGGCCCCCGGTTGGGAAGGCCGTTTGCGGATACAGTAAACGATTCTGCCTTTTCGA
ATATGAAAGAGCTGCGCATTCAGCATCAAGGTAGACCCATCCGAGCTTTCTTTGTATTTGACCCTTCTCGTTGTGGCATC
GTGTTATGCGCCGGAGATAAAACAGGGTTAAATGAAAAGAGATTCTATAAAGATATGATCAAGCTTGCAGATGCTGAGTA
CCGTAAGCACCTTAATCAGTAA
ATGTGGGATGTTGAAACAACGGAGGTTTTTGACAAGTGGTTTGAGGCGCAGACCGAAGCGCTCAAAGAGGATATGCTCGC
CGCAATGGTGATCTTATCCGAGTATGGCCCCCGGTTGGGAAGGCCGTTTGCGGATACAGTAAACGATTCTGCCTTTTCGA
ATATGAAAGAGCTGCGCATTCAGCATCAAGGTAGACCCATCCGAGCTTTCTTTGTATTTGACCCTTCTCGTTGTGGCATC
GTGTTATGCGCCGGAGATAAAACAGGGTTAAATGAAAAGAGATTCTATAAAGATATGATCAAGCTTGCAGATGCTGAGTA
CCGTAAGCACCTTAATCAGTAA
Antitoxin
Download Length: 100 a.a. Molecular weight: 10966.87 Da Isoelectric Point: 9.7256
>AT28036 WP_014227313.1 NC_018106:c5993854-5993555 [Klebsiella michiganensis E718]
MATLKELMAKQSPESQARIAEKVEEMRQAIALSMLREELNMSQAELAKAMGVKQPTIAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPTGKRIAFHL
MATLKELMAKQSPESQARIAEKVEEMRQAIALSMLREELNMSQAELAKAMGVKQPTIAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPTGKRIAFHL
Download Length: 300 bp
>AT28036 NC_018106:c5993854-5993555 [Klebsiella michiganensis E718]
ATGGCGACCCTTAAAGAATTAATGGCCAAACAGAGCCCGGAAAGCCAGGCGCGTATTGCTGAAAAAGTCGAGGAGATGCG
CCAGGCTATCGCTTTAAGTATGTTAAGGGAAGAACTCAATATGTCTCAGGCAGAGCTGGCTAAGGCAATGGGCGTTAAAC
AACCCACCATAGCAAAAATGGAACAGGCTGATAACGACCCGCGTTTGTCAACGCTGAAGCGCTATGTTGCAGCGCTCGGG
GGGGAACTCAGTATTGATGTTAAGCTGCCAACCGGTAAGCGAATCGCATTCCATCTTTAA
ATGGCGACCCTTAAAGAATTAATGGCCAAACAGAGCCCGGAAAGCCAGGCGCGTATTGCTGAAAAAGTCGAGGAGATGCG
CCAGGCTATCGCTTTAAGTATGTTAAGGGAAGAACTCAATATGTCTCAGGCAGAGCTGGCTAAGGCAATGGGCGTTAAAC
AACCCACCATAGCAAAAATGGAACAGGCTGATAACGACCCGCGTTTGTCAACGCTGAAGCGCTATGTTGCAGCGCTCGGG
GGGGAACTCAGTATTGATGTTAAGCTGCCAACCGGTAAGCGAATCGCATTCCATCTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3H3K0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3H3Q5 |