Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2917241..2917843 Replicon chromosome
Accession NZ_CP124460
Organism Escherichia coli strain AVS0947

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QJP79_RS14220 Protein ID WP_000897302.1
Coordinates 2917241..2917552 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJP79_RS14225 Protein ID WP_000356397.1
Coordinates 2917553..2917843 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP79_RS14195 (2913155) 2913155..2913754 + 600 WP_001296610.1 glucose-1-phosphatase -
QJP79_RS14200 (2913748) 2913748..2914620 + 873 WP_000920762.1 virulence factor BrkB family protein -
QJP79_RS14205 (2914617) 2914617..2915054 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QJP79_RS14210 (2915099) 2915099..2916040 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QJP79_RS14215 (2916104) 2916104..2917012 - 909 WP_001385591.1 alpha/beta hydrolase -
QJP79_RS14220 (2917241) 2917241..2917552 + 312 WP_000897302.1 hypothetical protein Toxin
QJP79_RS14225 (2917553) 2917553..2917843 + 291 WP_000356397.1 NadS family protein Antitoxin
QJP79_RS14230 (2918202) 2918202..2918480 + 279 WP_001296612.1 hypothetical protein -
QJP79_RS14235 (2918877) 2918877..2919095 + 219 WP_001251293.1 CopG family transcriptional regulator -
QJP79_RS14240 (2919280) 2919280..2920020 - 741 WP_000608806.1 hypothetical protein -
QJP79_RS14245 (2920045) 2920045..2920893 - 849 WP_001038650.1 hypothetical protein -
QJP79_RS14250 (2921183) 2921183..2921425 + 243 WP_001068514.1 CopG family transcriptional regulator -
QJP79_RS14255 (2921607) 2921607..2922536 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T280355 WP_000897302.1 NZ_CP124460:2917241-2917552 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT280355 WP_000356397.1 NZ_CP124460:2917553-2917843 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References