Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2105138..2105937 Replicon chromosome
Accession NZ_CP124460
Organism Escherichia coli strain AVS0947

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP79_RS10250 Protein ID WP_000347251.1
Coordinates 2105473..2105937 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP79_RS10245 Protein ID WP_001296435.1
Coordinates 2105138..2105473 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP79_RS10230 (2100923) 2100923..2101693 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QJP79_RS10235 (2101709) 2101709..2103043 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP79_RS10240 (2103418) 2103418..2104989 + 1572 WP_001273763.1 galactarate dehydratase -
QJP79_RS10245 (2105138) 2105138..2105473 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP79_RS10250 (2105473) 2105473..2105937 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP79_RS10255 (2105992) 2105992..2106801 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP79_RS10260 (2107050) 2107050..2108330 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP79_RS10265 (2108353) 2108353..2108826 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP79_RS10270 (2108837) 2108837..2109616 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP79_RS10275 (2109606) 2109606..2110484 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP79_RS10280 (2110502) 2110502..2110936 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T280353 WP_000347251.1 NZ_CP124460:2105473-2105937 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT280353 WP_001296435.1 NZ_CP124460:2105138-2105473 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References