Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2063430..2064157 Replicon chromosome
Accession NZ_CP124460
Organism Escherichia coli strain AVS0947

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag QJP79_RS10020 Protein ID WP_000550189.1
Coordinates 2063843..2064157 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJP79_RS10015 Protein ID WP_000560269.1
Coordinates 2063430..2063846 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP79_RS10005 (2058790) 2058790..2061141 + 2352 WP_000695432.1 alpha-glucosidase -
QJP79_RS10010 (2061367) 2061367..2063385 + 2019 WP_000121413.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
QJP79_RS10015 (2063430) 2063430..2063846 - 417 WP_000560269.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
QJP79_RS10020 (2063843) 2063843..2064157 - 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
QJP79_RS10025 (2064442) 2064442..2065578 - 1137 WP_000018703.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
QJP79_RS10030 (2065663) 2065663..2066166 + 504 WP_001295542.1 M48 family metallopeptidase -
QJP79_RS10035 (2066243) 2066243..2066935 + 693 WP_000942551.1 vancomycin high temperature exclusion protein -
QJP79_RS10040 (2067014) 2067014..2068000 + 987 WP_001385498.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T280352 WP_000550189.1 NZ_CP124460:c2064157-2063843 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15023.47 Da        Isoelectric Point: 4.4547

>AT280352 WP_000560269.1 NZ_CP124460:c2063846-2063430 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFVEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References