Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 840578..841080 Replicon chromosome
Accession NZ_CP124460
Organism Escherichia coli strain AVS0947

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag QJP79_RS04405 Protein ID WP_000767819.1
Coordinates 840578..840832 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag QJP79_RS04410 Protein ID WP_001259253.1
Coordinates 840829..841080 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP79_RS04380 (836396) 836396..836854 - 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -
QJP79_RS04385 (837071) 837071..838429 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
QJP79_RS04390 (838419) 838419..838481 - 63 WP_010723108.1 membrane protein YoeI -
QJP79_RS04395 (838696) 838696..839625 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP79_RS04400 (839671) 839671..840495 - 825 WP_000754737.1 SDR family oxidoreductase -
QJP79_RS04405 (840578) 840578..840832 - 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP79_RS04410 (840829) 840829..841080 - 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP79_RS04415 (841363) 841363..841413 + 51 WP_001364200.1 his operon leader peptide -
QJP79_RS04420 (841559) 841559..842458 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP79_RS04425 (842464) 842464..843768 + 1305 WP_001296211.1 histidinol dehydrogenase -
QJP79_RS04430 (843765) 843765..844835 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
QJP79_RS04435 (844835) 844835..845902 + 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 836396..836854 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T280349 WP_000767819.1 NZ_CP124460:c840832-840578 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT280349 WP_001259253.1 NZ_CP124460:c841080-840829 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References