Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 5133422..5134024 Replicon chromosome
Accession NZ_CP124455
Organism Escherichia coli strain AVS0193

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QJP76_RS25225 Protein ID WP_000897302.1
Coordinates 5133422..5133733 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJP76_RS25230 Protein ID WP_000356397.1
Coordinates 5133734..5134024 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP76_RS25200 (5129336) 5129336..5129935 + 600 WP_001296610.1 glucose-1-phosphatase -
QJP76_RS25205 (5129929) 5129929..5130801 + 873 WP_000920762.1 virulence factor BrkB family protein -
QJP76_RS25210 (5130798) 5130798..5131235 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QJP76_RS25215 (5131280) 5131280..5132221 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QJP76_RS25220 (5132285) 5132285..5133193 - 909 WP_001385591.1 alpha/beta hydrolase -
QJP76_RS25225 (5133422) 5133422..5133733 + 312 WP_000897302.1 hypothetical protein Toxin
QJP76_RS25230 (5133734) 5133734..5134024 + 291 WP_000356397.1 NadS family protein Antitoxin
QJP76_RS25235 (5134383) 5134383..5134661 + 279 WP_001296612.1 hypothetical protein -
QJP76_RS25240 (5135058) 5135058..5135276 + 219 WP_001251293.1 CopG family transcriptional regulator -
QJP76_RS25245 (5135461) 5135461..5136201 - 741 WP_000608806.1 hypothetical protein -
QJP76_RS25250 (5136226) 5136226..5137074 - 849 WP_001038650.1 hypothetical protein -
QJP76_RS25255 (5137364) 5137364..5137606 + 243 WP_001068514.1 CopG family transcriptional regulator -
QJP76_RS25260 (5137788) 5137788..5138717 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T280336 WP_000897302.1 NZ_CP124455:5133422-5133733 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT280336 WP_000356397.1 NZ_CP124455:5133734-5134024 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References