Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4271429..4272228 Replicon chromosome
Accession NZ_CP124455
Organism Escherichia coli strain AVS0193

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP76_RS21000 Protein ID WP_000347251.1
Coordinates 4271764..4272228 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP76_RS20995 Protein ID WP_001296435.1
Coordinates 4271429..4271764 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP76_RS20980 (4267214) 4267214..4267984 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QJP76_RS20985 (4268000) 4268000..4269334 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP76_RS20990 (4269709) 4269709..4271280 + 1572 WP_001273763.1 galactarate dehydratase -
QJP76_RS20995 (4271429) 4271429..4271764 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP76_RS21000 (4271764) 4271764..4272228 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP76_RS21005 (4272283) 4272283..4273092 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP76_RS21010 (4273341) 4273341..4274621 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP76_RS21015 (4274644) 4274644..4275117 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP76_RS21020 (4275128) 4275128..4275907 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP76_RS21025 (4275897) 4275897..4276775 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP76_RS21030 (4276793) 4276793..4277227 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T280333 WP_000347251.1 NZ_CP124455:4271764-4272228 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT280333 WP_001296435.1 NZ_CP124455:4271429-4271764 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References