Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3016390..3016992 Replicon chromosome
Accession NZ_CP124442
Organism Escherichia coli strain AVS0196

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QJP94_RS14920 Protein ID WP_000897302.1
Coordinates 3016390..3016701 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJP94_RS14925 Protein ID WP_000356397.1
Coordinates 3016702..3016992 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP94_RS14895 (3012304) 3012304..3012903 + 600 WP_001296610.1 glucose-1-phosphatase -
QJP94_RS14900 (3012897) 3012897..3013769 + 873 WP_000920762.1 virulence factor BrkB family protein -
QJP94_RS14905 (3013766) 3013766..3014203 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QJP94_RS14910 (3014248) 3014248..3015189 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QJP94_RS14915 (3015253) 3015253..3016161 - 909 WP_001385591.1 alpha/beta hydrolase -
QJP94_RS14920 (3016390) 3016390..3016701 + 312 WP_000897302.1 hypothetical protein Toxin
QJP94_RS14925 (3016702) 3016702..3016992 + 291 WP_000356397.1 NadS family protein Antitoxin
QJP94_RS14930 (3017351) 3017351..3017629 + 279 WP_001296612.1 hypothetical protein -
QJP94_RS14935 (3018026) 3018026..3018244 + 219 WP_001251293.1 CopG family transcriptional regulator -
QJP94_RS14940 (3018429) 3018429..3019169 - 741 WP_000608806.1 hypothetical protein -
QJP94_RS14945 (3019194) 3019194..3020042 - 849 WP_001038650.1 hypothetical protein -
QJP94_RS14950 (3020332) 3020332..3020574 + 243 WP_001068514.1 CopG family transcriptional regulator -
QJP94_RS14955 (3020756) 3020756..3021685 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T280293 WP_000897302.1 NZ_CP124442:3016390-3016701 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT280293 WP_000356397.1 NZ_CP124442:3016702-3016992 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References