Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2203691..2204490 Replicon chromosome
Accession NZ_CP124442
Organism Escherichia coli strain AVS0196

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP94_RS10940 Protein ID WP_000347251.1
Coordinates 2204026..2204490 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP94_RS10935 Protein ID WP_001296435.1
Coordinates 2203691..2204026 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP94_RS10920 (2199476) 2199476..2200246 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QJP94_RS10925 (2200262) 2200262..2201596 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP94_RS10930 (2201971) 2201971..2203542 + 1572 WP_001273763.1 galactarate dehydratase -
QJP94_RS10935 (2203691) 2203691..2204026 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP94_RS10940 (2204026) 2204026..2204490 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP94_RS10945 (2204545) 2204545..2205354 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP94_RS10950 (2205603) 2205603..2206883 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP94_RS10955 (2206906) 2206906..2207379 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP94_RS10960 (2207390) 2207390..2208169 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP94_RS10965 (2208159) 2208159..2209037 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP94_RS10970 (2209055) 2209055..2209489 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T280291 WP_000347251.1 NZ_CP124442:2204026-2204490 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT280291 WP_001296435.1 NZ_CP124442:2203691-2204026 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References