Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3015110..3015712 Replicon chromosome
Accession NZ_CP124436
Organism Escherichia coli strain AVS0790

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QJP66_RS14905 Protein ID WP_000897302.1
Coordinates 3015110..3015421 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJP66_RS14910 Protein ID WP_000356397.1
Coordinates 3015422..3015712 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP66_RS14880 (3011024) 3011024..3011623 + 600 WP_001296610.1 glucose-1-phosphatase -
QJP66_RS14885 (3011617) 3011617..3012489 + 873 WP_000920762.1 virulence factor BrkB family protein -
QJP66_RS14890 (3012486) 3012486..3012923 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QJP66_RS14895 (3012968) 3012968..3013909 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QJP66_RS14900 (3013973) 3013973..3014881 - 909 WP_001385591.1 alpha/beta hydrolase -
QJP66_RS14905 (3015110) 3015110..3015421 + 312 WP_000897302.1 hypothetical protein Toxin
QJP66_RS14910 (3015422) 3015422..3015712 + 291 WP_000356397.1 NadS family protein Antitoxin
QJP66_RS14915 (3016071) 3016071..3016349 + 279 WP_001296612.1 hypothetical protein -
QJP66_RS14920 (3016746) 3016746..3016964 + 219 WP_001251293.1 CopG family transcriptional regulator -
QJP66_RS14925 (3017149) 3017149..3017889 - 741 WP_000608806.1 hypothetical protein -
QJP66_RS14930 (3017914) 3017914..3018762 - 849 WP_001038650.1 hypothetical protein -
QJP66_RS14935 (3019052) 3019052..3019294 + 243 WP_001068514.1 CopG family transcriptional regulator -
QJP66_RS14940 (3019476) 3019476..3020405 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T280262 WP_000897302.1 NZ_CP124436:3015110-3015421 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT280262 WP_000356397.1 NZ_CP124436:3015422-3015712 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References