Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2203182..2203981 Replicon chromosome
Accession NZ_CP124436
Organism Escherichia coli strain AVS0790

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP66_RS10935 Protein ID WP_000347251.1
Coordinates 2203517..2203981 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP66_RS10930 Protein ID WP_001296435.1
Coordinates 2203182..2203517 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP66_RS10915 (2198967) 2198967..2199737 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QJP66_RS10920 (2199753) 2199753..2201087 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP66_RS10925 (2201462) 2201462..2203033 + 1572 WP_001273763.1 galactarate dehydratase -
QJP66_RS10930 (2203182) 2203182..2203517 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP66_RS10935 (2203517) 2203517..2203981 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP66_RS10940 (2204036) 2204036..2204845 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP66_RS10945 (2205094) 2205094..2206374 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP66_RS10950 (2206397) 2206397..2206870 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP66_RS10955 (2206881) 2206881..2207660 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP66_RS10960 (2207650) 2207650..2208528 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP66_RS10965 (2208546) 2208546..2208980 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T280260 WP_000347251.1 NZ_CP124436:2203517-2203981 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT280260 WP_001296435.1 NZ_CP124436:2203182-2203517 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References