Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4130355..4131154 Replicon chromosome
Accession NZ_CP124429
Organism Escherichia coli strain AVS0051

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP74_RS20120 Protein ID WP_000347251.1
Coordinates 4130690..4131154 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP74_RS20115 Protein ID WP_001296435.1
Coordinates 4130355..4130690 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP74_RS20100 (4126140) 4126140..4126910 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QJP74_RS20105 (4126926) 4126926..4128260 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP74_RS20110 (4128635) 4128635..4130206 + 1572 WP_001273763.1 galactarate dehydratase -
QJP74_RS20115 (4130355) 4130355..4130690 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP74_RS20120 (4130690) 4130690..4131154 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP74_RS20125 (4131209) 4131209..4132018 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP74_RS20130 (4132267) 4132267..4133547 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP74_RS20135 (4133570) 4133570..4134043 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP74_RS20140 (4134054) 4134054..4134833 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP74_RS20145 (4134823) 4134823..4135701 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP74_RS20150 (4135719) 4135719..4136153 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T280234 WP_000347251.1 NZ_CP124429:4130690-4131154 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT280234 WP_001296435.1 NZ_CP124429:4130355-4130690 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References