Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2842822..2843324 Replicon chromosome
Accession NZ_CP124429
Organism Escherichia coli strain AVS0051

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag QJP74_RS14185 Protein ID WP_000767819.1
Coordinates 2842822..2843076 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag QJP74_RS14190 Protein ID WP_001259253.1
Coordinates 2843073..2843324 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP74_RS14160 (2838640) 2838640..2839098 - 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -
QJP74_RS14165 (2839315) 2839315..2840673 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
QJP74_RS14170 (2840663) 2840663..2840725 - 63 WP_010723108.1 membrane protein YoeI -
QJP74_RS14175 (2840940) 2840940..2841869 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP74_RS14180 (2841915) 2841915..2842739 - 825 WP_000754737.1 SDR family oxidoreductase -
QJP74_RS14185 (2842822) 2842822..2843076 - 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP74_RS14190 (2843073) 2843073..2843324 - 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP74_RS14195 (2843607) 2843607..2843657 + 51 WP_001364200.1 his operon leader peptide -
QJP74_RS14200 (2843803) 2843803..2844702 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP74_RS14205 (2844708) 2844708..2846012 + 1305 WP_001296211.1 histidinol dehydrogenase -
QJP74_RS14210 (2846009) 2846009..2847079 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
QJP74_RS14215 (2847079) 2847079..2848146 + 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2838640..2839098 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T280230 WP_000767819.1 NZ_CP124429:c2843076-2842822 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT280230 WP_001259253.1 NZ_CP124429:c2843324-2843073 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References