Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2853805..2854407 Replicon chromosome
Accession NZ_CP124424
Organism Escherichia coli strain AVS0247

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QJB03_RS13830 Protein ID WP_000897302.1
Coordinates 2853805..2854116 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJB03_RS13835 Protein ID WP_000356397.1
Coordinates 2854117..2854407 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB03_RS13805 (2849719) 2849719..2850318 + 600 WP_001296610.1 glucose-1-phosphatase -
QJB03_RS13810 (2850312) 2850312..2851184 + 873 WP_000920762.1 virulence factor BrkB family protein -
QJB03_RS13815 (2851181) 2851181..2851618 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QJB03_RS13820 (2851663) 2851663..2852604 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QJB03_RS13825 (2852668) 2852668..2853576 - 909 WP_001385591.1 alpha/beta hydrolase -
QJB03_RS13830 (2853805) 2853805..2854116 + 312 WP_000897302.1 hypothetical protein Toxin
QJB03_RS13835 (2854117) 2854117..2854407 + 291 WP_000356397.1 NadS family protein Antitoxin
QJB03_RS13840 (2854766) 2854766..2855044 + 279 WP_001296612.1 hypothetical protein -
QJB03_RS13845 (2855441) 2855441..2855659 + 219 WP_001251293.1 CopG family transcriptional regulator -
QJB03_RS13850 (2855844) 2855844..2856584 - 741 WP_000608806.1 hypothetical protein -
QJB03_RS13855 (2856609) 2856609..2857457 - 849 WP_001038650.1 hypothetical protein -
QJB03_RS13860 (2857747) 2857747..2857989 + 243 WP_001068514.1 CopG family transcriptional regulator -
QJB03_RS13865 (2858171) 2858171..2859100 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T280190 WP_000897302.1 NZ_CP124424:2853805-2854116 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT280190 WP_000356397.1 NZ_CP124424:2854117-2854407 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References