Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2051127..2051926 Replicon chromosome
Accession NZ_CP124424
Organism Escherichia coli strain AVS0247

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJB03_RS09900 Protein ID WP_000347251.1
Coordinates 2051462..2051926 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJB03_RS09895 Protein ID WP_001296435.1
Coordinates 2051127..2051462 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB03_RS09880 (2046912) 2046912..2047682 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QJB03_RS09885 (2047698) 2047698..2049032 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJB03_RS09890 (2049407) 2049407..2050978 + 1572 WP_001273763.1 galactarate dehydratase -
QJB03_RS09895 (2051127) 2051127..2051462 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJB03_RS09900 (2051462) 2051462..2051926 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJB03_RS09905 (2051981) 2051981..2052790 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJB03_RS09910 (2053039) 2053039..2054319 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJB03_RS09915 (2054342) 2054342..2054815 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJB03_RS09920 (2054826) 2054826..2055605 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJB03_RS09925 (2055595) 2055595..2056473 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJB03_RS09930 (2056491) 2056491..2056925 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T280188 WP_000347251.1 NZ_CP124424:2051462-2051926 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT280188 WP_001296435.1 NZ_CP124424:2051127-2051462 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References