Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3387813..3388415 Replicon chromosome
Accession NZ_CP124420
Organism Escherichia coli strain AVS0155

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QJP63_RS16715 Protein ID WP_000897302.1
Coordinates 3387813..3388124 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJP63_RS16720 Protein ID WP_000356397.1
Coordinates 3388125..3388415 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP63_RS16690 (3383727) 3383727..3384326 + 600 WP_001296610.1 glucose-1-phosphatase -
QJP63_RS16695 (3384320) 3384320..3385192 + 873 WP_000920762.1 virulence factor BrkB family protein -
QJP63_RS16700 (3385189) 3385189..3385626 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QJP63_RS16705 (3385671) 3385671..3386612 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QJP63_RS16710 (3386676) 3386676..3387584 - 909 WP_001385591.1 alpha/beta hydrolase -
QJP63_RS16715 (3387813) 3387813..3388124 + 312 WP_000897302.1 hypothetical protein Toxin
QJP63_RS16720 (3388125) 3388125..3388415 + 291 WP_000356397.1 NadS family protein Antitoxin
QJP63_RS16725 (3388774) 3388774..3389052 + 279 WP_001296612.1 hypothetical protein -
QJP63_RS16730 (3389449) 3389449..3389667 + 219 WP_001251293.1 CopG family transcriptional regulator -
QJP63_RS16735 (3389852) 3389852..3390592 - 741 WP_000608806.1 hypothetical protein -
QJP63_RS16740 (3390617) 3390617..3391465 - 849 WP_001038650.1 hypothetical protein -
QJP63_RS16745 (3391755) 3391755..3391997 + 243 WP_001068514.1 CopG family transcriptional regulator -
QJP63_RS16750 (3392179) 3392179..3393108 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T280163 WP_000897302.1 NZ_CP124420:3387813-3388124 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT280163 WP_000356397.1 NZ_CP124420:3388125-3388415 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References